Gastroprotective effect of plantago major L.against gastric injury induced by aspirin in rats.

M Kobeasy, O. M. Abdel-Fatah, S. M. Abd El-Salam, z. M. Mohamed


Ethanolic and water extracts from leaves and seeds of plantago major L.were evaluated for their potential anti-ulcerogenic effects using aspirin induced gastric ulcerations in rats . Oral administration of ethanol and water extracts (1000 mg/kg body weight) of plantago major L.. Leaves and seeds significantly decreased the ulcer index, total acidity compared with positive control and ethanolic extract of p.major leaves at (1000 mg/kg body weight) has significant highest reduction of the ulcer index and total acidity of gastric fluid compared with other extracts . Moreover, serum levels of aspartate transaminase (AST) , alanine transaminase (ALT) were significantly (p< 0.05) decreased by all groups which received tested extracts compared to positive control. Also,results of hitopathological examination of rats stomach demonstrated the protective effect of the plant extracts under study .


P.S. Phull, C.J Green, and M.R Jacyna. Am. J. Gastroenterol. Hepatol. 7 (1995) 265–274.

W. Toma, C. A. Hiruma-Lima, R. O. Guerrer and A. R. Souza. Phytomedicine. 12 (2005) 345-350.

W.Mao-ye and Liguo .J.Med.plant Res.5(9) (2011).1659 -1663

M.M. Wolfe and G. Sachs. Gastroenterol. 118, 59–531.

K. Biswas, I. Chattopadhyay, R.K. Banerjee and U. Bandyopadhyay . Curr.Sci. 82 (2003) 1336–1345.

A. Martelli, F. Martelli, E. Mereto, G. Brambilla Compart, D. Sini, R. Bergamaschi and G. Brabilla,. Toxicology 30 (1998) 19–41.

B.G. Katzung. Basic and clinical pharmacology, ninth ed. Mc Graw-Hill Companies. 8(2004). p. 1009.

Y.H. Wang, X.L. Yang, L. Wang, M.X. Cui, Y.Q. Cai, X.L. Li andY.J. Wu. J. Physiol. Pharmacol. 88 (9) (2010)


A.S.Awaad , R.M.El-Meligy and G.A.Soliman .J.saudi chem.soc.17 (2013) .101-124.

A.B. Samuelsen. J. Ethnopharmacol .71 (2000) 1-21.

A.R. Mc Cutcheon, T.E. Roberts and E. Gibbons.

J. Ethnopharmacol. 49(1995) 101-110

E. Yesilada, E. Sezik, T. Fujita , S. Tanaka and M. Tabata. Phytotherap.7 (1993) 263-265.

S.M. Choi, J.H. Shin, K.K. Kang, B.O. Ahn and M. Yoo.

Dis. Sci. 52 ( 2007) 3075–3080.

M. I. Kobeasy,O. M. Abdel-Fatah, S. M. Abd El-Salam and Z.M. Mohamed. Int. J. Biodvers. Conserv. 3(3) (2011) 83-91.

S. Kaur, C. Vaishnavi, K.K. Prasad, P. Ray and R. Kochhar. Ind. J. Med. Res. 133 (2011) 434-441.

A .O .A .C. Official Methods of Analysis of AOAC international 17th Ed. Association of Official Analytical Chemists, Washington.11 (2000).200.

A. H. Atta, S. M. Nasr and S. M. Mouneir. Nat Prod Rad. 4 (2005) 258–263.

B. L. Oser and, P. B. Hawk .Physiological Chemistry, 14th ed. (Ed.Hill, M.) Book Company, NewYork, USA12 (1947). 1472.

C. H. Cho and C. W. Ogle. J. Pharmacol. 48(1978) 97-105.

A. Reitman and S. Frankel. Am. J. Clin. 28 (1957) 56-63.

H. M. Carleton (1967). Histological Technique, 4th ed. New York, Oxford University Press.

G. W Snedecor and G.W. Cochran Statistical Methods.6 th Ed.The Iowa State University Press.Ams USA.17 (1982).680.

W.M, Waller and D.B Duncan. A Bayes rule for the symmetric multiple comparison problem, J. Am. Statistical Assoc. 64 (1969) .1484-1499

O,Gokhan,S.Ekin,H.Ozdemir,H.Demir,S.Yasar,A.Levent,IBerber and B.Kaki .Asian pacific J.cancer prev.12 (2011)531-535.

M.A.Abud,A.Molina,G.H.Wendel,E.J.Hikawczuk,E.Pelzer ,O.Marla and R.Saad.Lat.Am.J.Pharm.31(2012).1203-1206.

P.H.M. Nunes, P.M.S. Cavalcanti, S.M.P. Galvao and

M.C.C. Martins. Pharmazie 64 (1) ( 2009) 58–62.

R. Ramasubramaniaraja1 and M. N. Babu An Overview. Life Sciences. 75(2011) 2867–2878

A.E. Ligha, H.B. Fawehinmi. Pak. J. Nutr. 8 (10) (2009) 1532–1536.

Z. Pour Ismail, R. Shouri Bidgoli and E. Zaragari

J. med. sci . 3(2009) 175-179.

L.C.Chiang ,W. Chiang ,M.Y.Chang and C.C.Lin.Antiviral Res.55(2002) 53-62.

Full Text: PDF


  • There are currently no refbacks.

Bookmark and Share

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.